· 05:30 PM PDT

Qwen3.8 Optimizations Dominate as AI Markets and Agents Reshape

Overview

The community is deeply focused on local inference breakthroughs, with Qwen3.8-27B dominating discussions through aggressive speculative decoding techniques that dramatically boost token speeds on consumer GPUs. Meanwhile, the industry landscape is shifting rapidly as Anthropic outpaces OpenAI in revenue growth, Moderna secures landmark AI-driven vaccine results, and Stripe declares the singularity has arrived. Real-world agent applications are accelerating, from autonomously patching firmware and decompiling legacy games to raising urgent concerns about educational dependency, parasocial reliance, and self-propagating "mind viruses".


Hacker News Stories

Claude Code teaching macOS to natively print to the HP Laser 1008a

129 points · 3 comments · by amrrs

Claude Code teaching macOS to natively print to the HP Laser 1008a

A developer used Claude Code with Opus 4.8 and a 1M context window to reverse-engineer the SPL3 raster language and create native printing support for the HP Laser 1008a, a printer HP never officially supported on macOS. The project involved running HP's proprietary driver inside a Linux VM on macOS and bridging it to the Mac printing subsystem, effectively teaching macOS to natively print to hardware that has no Mac driver.

Interesting Points
  • The project reverse-engineered HP's SPL3 raster language from scratch to understand the printer's native protocol.
  • HP's actual codec was run inside a Linux container on macOS rather than being rewritten natively.
  • The entire session took approximately 4 hours in one sitting, demonstrating how AI coding agents can tackle hardware driver problems that would normally require weeks of reverse engineering.
  • The resulting driver requires a root launcher from the user's ~/.hp1008 directory, which some commenters flagged as a security concern.
Top Comments

Unfortunately this is a very misleading post. I don't doubt the end result - it's useful that it works, but it's not "natively" and, unlike what some people assume, Claude didn't write a driver. It basically used HP's existing proprietary driver in a Linux VM on macOS, and just bridged that to macOS.

It also requires a root launcher that runs code from the user ~/.hp1008 dir, so security is weakened.

Tiberium (1 reply)


Mathematics in the Age of AI

115 points · 107 comments · by jonbaer

Mathematics in the Age of AI

Terence Tao's essay, presented at the 2026 International Congress of Mathematicians, examines how the mathematical community should adapt to artificial intelligence capable of research-level tasks. Instead of debating when or if such AI will emerge, the author treats its arrival as a given to explore the fundamental goals and values of mathematical research. Using mathematical problem-solving as a case study, the piece argues that the discipline must pivot its focus from pure computation to deeper conceptual and methodological questions.

Interesting Points
  • The author treats the arrival of research-level AI as a conditional certainty rather than a speculative debate.
  • Tao proposes a rule of thumb for mathematical publishing: if authors cannot convincingly demonstrate they can give a clear, expert-level talk on their results, the result should not be published.
  • The essay shifts the disciplinary focus from technical capabilities to the underlying goals and values of mathematics.
  • A commenter notes that not using AI puts one at a huge disadvantage in a career setting, as AI can find deep references better than humans and actually do the math.
Top Comments

Tao's Rule of Thumb (which applies very well to software):

My own suggested rule of thumb: if the authors cannot convincingly demonstrate that they are able to give a clear, expert-level talk on their results, one that is correct and properly attributed, then the result should not be published. A proof that no human can properly explain should be viewed as incomplete, even if it has been formally verified.

sonicrocketman (10 replies)

The problem with that rule of thumb is that unless there's some status/reward for completing the result, it won't happen. People will just put up the formally verified result and call it a day, and there's no incentive for them or anyone else to clean things up.

We'll end up with incomprehensible math because comprehensibility isn't rewarded. No one is going to get a Fields Medal, or tenure, for digesting someone else's results.

pfdietz (2 replies)

AI also can replace a lot of expert attention too. Why not? What is useful or what is not useful is based on the expert's narrow opinion. An AI system can do much more and deep value comparison. It looks like if our current technological advancement continues, in the space of what is possible (or even impossible), AI can find the optimal solutions better than any human or human organizations. But I think there is only one think will remain for humans to go for these solutions: what we value. that will be the last resort I believe and hopefully ai systems won't start manipulate us too as we are very fragile on manipulation.

caglaroktay (1 reply)

I think it's impossible to be half in. AI will eventually be better at things than people, and people will simply be rocks in the gears of progress.

The only thing to do is to be all in, or get run over.

a2ff6eeb0 (1 reply)

Not using AI puts one at a huge disadvantage in a career setting. Ai can find deep references better than humans now, let alone actually doing the math. The challenge is knowing which problems to tackle given the cost limitations. If you have $10k to spend on tokens, you have to choose problems that can conceivably be solved within this budget.

paulpauper (0 replies)


Feature Request: Support AGENTS.md

114 points · 60 comments · by fg137

A GitHub user has requested that Anthropic's Claude Code add native support for AGENTS.md, a standardized Markdown file designed to help AI coding agents understand project context. The proposal highlights that competitors like Codex, Amp, and Cursor are increasingly adopting this format, while Claude's current CLAUDE.md file is viewed as too platform-specific. Implementing AGENTS.md would reportedly improve cross-tool compatibility and streamline collaboration among developers who use different AI coding assistants.

Interesting Points
  • The standardization effort is anchored by the agents.md website, signaling an industry-wide push for a unified developer format.
  • Claude Code currently relies on a project-specific CLAUDE.md file, which lacks interoperability with other AI coding platforms.
  • The issue explicitly names Codex, Amp, and Cursor as early adopters of the AGENTS.md standard.
  • The request is tagged with area:core and memory labels, indicating it would affect foundational system instructions rather than just UI tweaks.
  • A related pull request exists in a community fork (Piebald-AI/tweakcc#459), suggesting existing community workarounds ahead of official support.
Top Comments

My Claude.md has one line that says to read agents.md, this is a bit of a nothingburger

chomp (4 replies)

The obvious reason is that they would prefer to have CLAUDE.md files in every repo (even if it's just a symlink to AGENTS.md). It serves as a free advertisement for them. Same reason as for auto-adding attribution text in commit messages, etc. It's the "Sent from my iPhone" of our time.

OleksandrC (3 replies)

While I agree with your analysis, I think Hanlon's razor applies here – CLAUDE.md has probably just been hardcoded, the same way "master" used to be the hardcoded default in Git. If it was for advertising, Claude would equally recognize CLAUDE.adoc, CLAUDE.txt or CLAUDE files.

Diti (7 replies)

It would take like 30s of vibe-coding (including writing the prompt) to add support for AGENTS.md to claude code.

fastball (0 replies)

Why not symlink AGENTS.md to CLAUD.md?

drivingmenuts (1 reply)


Launch HN: OneCLI (YC S26) – OSS sandboxed agent harness for teams

51 points · 14 comments · by guyb3

OneCLI is an open-source platform designed to deploy and manage AI agents at the team level rather than for individual users. It addresses the operational friction of multi-agent environments by provisioning a dedicated, sandboxed agent for each employee while centralizing secret management, permissions, and policy enforcement. The system routes all outbound agent traffic through a Rust-based gateway that intercepts requests to inject credentials securely, ensuring secrets never directly touch the agent itself. It supports both cloud and self-hosted deployments, integrates with corporate identity providers and Slack, and includes deterministic human-in-the-loop controls for high-risk operations.

Interesting Points
  • A Rust-based gateway performs MITM on outbound HTTPS requests to inject credentials as headers or query parameters, guaranteeing that agents never directly access or store sensitive keys.
  • The agent runner is strictly outbound-only with zero inbound ports, enabling deployment on laptops, homelabs, or NAT-restricted VPCs without requiring network tunneling or ingress rules.
  • Secrets are encrypted at rest using AES-256-GCM and decrypted only at request time, with access strictly matched to predefined host and path patterns.
  • The platform includes deterministic human-in-the-loop approval workflows directly within the chat interface for authorizing or blocking high-risk operations like database deletions or S3 bucket emptying.
Top Comments

How do you even win in this space? I feel like every day I see either a paid or fully OSS version of this product being posted here. As an end user I've become so overwhelmed that I've just started to mostly ignore them at this point. I can't be the only potential customer feeling this way?

aliasxneo (thread)

The important detail is whether approval binds to the exact proposed action, including the recipient, repository, issue, or data being sent, rather than just "allow Gmail" or "allow this endpoint." How granular are the gateway policies for APIs where read and write actions share the same host?

taoh (thread)

Keeping the real credential out of model context is a meaningful improvement, but the gateway still becomes a confused-deputy boundary. How granular are policies below the endpoint level? An agent allowed to call a CRM API may still be tricked into exporting the wrong customer or changing a field it should only read. I'd be interested in whether policies can constrain method, path, request fields, resource ownership, and response volume, and how those rules are tested against prompt injection.

ezzy-1630 (thread)


Show HN: Frugal Tokens – explore costs and usage across coding agents

26 points · 6 comments · by dpc94

Frugal Tokens is a local-first tool for exploring token costs and usage patterns across coding agents. It reads local conversation files and syncs them into a SQLite database, with a focus on identifying cache misses and per-session token expenditure. The tool provides a per-session explorer that lets developers inspect which parts of their workflow and project build pipeline are consuming the most tokens, helping teams measure ROI on token spend after a year of unrestrained agent usage.

Interesting Points
  • The tool focuses on cache miss detection, identifying sessions where stepping away for an hour or more caused the agent to re-process context that could have been cached.
  • It provides a per-session explorer for digging into individual conversations and seeing all tool calls and token breakdowns.
  • The tool is local-only, reading conversation files directly without API calls, and syncing into a SQLite database for analysis.
Top Comments

I can highly recommend https://agentsview.io/ for a way to dig into your LLM usage. It reads your local conversation files and provides a ton of visualizations as well as the ability to dig into each conversation and see all the tool calls/etc. It's incredibly powerful.

joshstrange (thread)

I have started using this to inspect some of my heavier sessions and it has helped uncover some of the parts of my workflow and my project's build pipeline that were really slowing me down.

I also had no idea how many cache misses were happening when I stepped away for an hour or more at times.

stephensilber (thread)

Really cool to see the difference in token usage across different harnesses.

These kind of independently-verified data points will be super important for companies (and individuals!) trying to measure RoI on token spend as they recover from letting people go wild on token usage in the past year.

gen220 (thread)


49 more Hacker News stories

Reddit Stories

Introducing Qwen3.8-27B Dynamic v3 Unsloth GGUFs

1094 points · 182 comments · r/LocalLLaMA · by u/danielhanchen

Introducing Qwen3.8-27B Dynamic v3 Unsloth GGUFs

Unsloth has released Dynamic v3.0 GGUF quantizations for the newly launched Qwen3.8-27B model, claiming superior accuracy and performance over competing quantizers. Built on the Qwen3.5 architecture, this 27-billion-parameter dense model introduces native vision-language capabilities, enhanced agentic planning, and flexible reasoning controls. The release provides extensive local deployment options through tools like llama.cpp, Ollama, and Unsloth Studio, with context lengths natively supporting 262,144 tokens and extendable to one million.

Interesting Points
  • Unsloth claims its Dynamic v3.0 method delivers over 10% better top-1% accuracy at the same size compared to every other GGUF provider.
  • The architecture utilizes a hidden layout of 16 blocks, each containing three Gated DeltaNet units and one Gated Attention unit, distributed across 64 layers, and is trained with multi-token prediction.
  • While native context length is 262,144 tokens, it can be extended to 1,000,000 tokens using RoPE scaling techniques like YaRN for long-horizon tasks.
  • For agentic workloads, Unsloth recommends allocating up to 262,144 tokens for internal reasoning content and 131,072 tokens for final output responses.
Top Comments

Just want to say, thank you Unsloth team for these great quants. Your hard work is appreciated!

u/Jorlen (272 points · permalink)

That's very nice. Can you also add a line for the previous Qwen 3.8 27B UD 2.0 quants to the graph, so that it's easier (or possible at all) to see how what most of us now have on disk compares to the latest and greatest? KLD and/or top-1 would probably be sufficient, I assume you still have that data from the previous quants.

u/Chromix_ (120 points · permalink)

15 gb for q4 km ? This could actually be cool if it doesn't really lose in quality.

u/koloved (47 points · permalink)

So we can now run IQ4XS on 16gb vram without mtp

u/Adventurous-Gold6413 (44 points · permalink)

Now that oobabooga is in your team, it sure would be cool to see those per category and KV cache quantization KLD numbers. :)

Like this:

https://preview.redd.it/65megeeh0dkh1.png?width=1500&format=png&auto=webp&s=ea874c59f636515f0dbf446687e034597ea678ed

late edit, forgot source: https://localbench.substack.com/

u/rerri (48 points · permalink)

Same story in 1 more subreddit: r/LocalLLaMA

updated unsloth/Qwen3.8-27B-GGUF · Hugging Face

235 points · 100 comments · r/LocalLLaMA · by u/jacek2023


Moderna stock, $MRNA , surges over +110% after announcing the first ever positive Phase 3 results for a personalized cancer vaccine.

851 points · 94 comments · r/singularity · by u/Fantastic-Emu-3819

Moderna stock, $MRNA , surges over +110% after announcing the first ever positive Phase 3 results for a personalized cancer vaccine.

Moderna stock surged over 110% after announcing the first ever positive Phase 3 results for a personalized cancer vaccine. The treatment, initially approved for melanoma, represents a breakthrough in mRNA-based cancer therapy. While the personalized nature of the treatment means it is inherently expensive at approximately $150,000 per person, commenters note that this is comparable to or less than the cost of traditional chemotherapy, surgery, and radiotherapy combined over years of treatment.

Interesting Points
  • The initial positive Phase 3 results are for melanoma, but there is hope the treatment could be effective against a larger variety of cancers.
  • The treatment costs approximately $150,000 per person, which commenters note is comparable to the total cost of traditional cancer therapies over years of treatment.
  • One commenter notes that a friend who went through cancer treatment cost the state far more than $150K when considering hospital stays, chemo, check-ups, and the burden on healthcare workers.
Top Comments

We cured cancer before gta 6

u/Famous-Reach-6730 (273 points · permalink)

Moderna being called MRNA is fucking hilarious i love it

u/Head-Needleworker849 (182 points · permalink)

So far this result is for melanoma, but there is a decent hope that this type of treatment to be effective against a larger variety of cancers. (though melanoma is uniquely suited to it).

The somewhat unfortunate news is that this type of treatment is inherently expensive, think in the order of magnitude of ~150k per person, so unless there is further huge developments in efficiency not cost effective for the whole world.

u/Dangerous-Sport-2347 (127 points · permalink)

Mapping the human genome was crazy expensive 30 years ago, it's like dirt cheap now. Same can happen here hopefully

u/das_war_ein_Befehl (108 points · permalink)

Chemotherapy, surgery, radiotherapy and all the other things combined cost a lot more than that 150k. Cancer therapy in socialised healthcare is a huuuuuuuuuge burden on everyone involved financially, emotionally and physically.

A friend of mine went through cancer recently, and the vast amount of hospital stays, chemo, check ups with oncologists etc. sure as hell cost the state a lot more than 150k on top of the time many people had to dedicate for her treatment from the receptionist taking her in to the nurses and doctors taking care of her. And lets not forget to mention the burden on my friends body for YEARS to come before she can be 100% back to normal, if at all.

If the state can just pay 150k and spare the year long process while the patient will just get a vaccine and might just feel a little bit fatigued for a week before the cancer is gone, its a win win for everyone involved.

u/ZaradimLako (56 points · permalink)


New midsize Qwen 3.8 model coming next week (hopefully) according to community manager!

517 points · 254 comments · r/LocalLLaMA · by u/sleepy_roger

The Qwen community manager mentioned in the Qwen Ambassador Discord that a new midsize open-weight model is coming next week. The community manager specifically noted that a 35B A3B model is not the one to wait for, suggesting the new model will be significantly larger. Community speculation ranges from 80B to 122B parameters, with many hoping for vision capabilities.

Interesting Points
  • The Qwen community manager stated that the 35B A3B model is not the upcoming release, implying a larger model is imminent.
  • Community members are hoping the new model includes vision capabilities, which would be valuable for coding tasks requiring UI verification.
  • The announcement has reignited excitement about the open-source model race between Qwen and DeepSeek.
  • A 122B model with 3.8 capabilities is considered by many to be the sweet spot for speed and world knowledge.
Top Comments

80b Qwen coder 🤞

u/boxwrenchx (259 points · permalink)

Yep, another comment from someone on the team was "...35B A3B isn't the one to wait for..."

u/cogitech2 (104 points · permalink)

Qwen 3.8 100ish b will a dsv4F killer

u/Gloomy_Letterhead395 (96 points · permalink)

This August is legendary, reminds me of the olds days! You know....3 years ago

u/boxwrenchx (88 points · permalink)

A new 122b with the 3.8 capabilities would be a game changer. It's truly the sweet spot for speed and world knowledge

u/whichsideisup (67 points · permalink)


Thoughts About Scaling Law - Z.ai

467 points · 102 comments · r/LocalLLaMA · by u/pmttyji

Thoughts About Scaling Law - Z.ai

Z.ai published a thoughtful analysis on scaling laws, arguing that parameter count alone is meaningless without considering data volume, compute allocation, and deployment conditions. The post discusses how GLM 5.3 achieves frontier-level performance at a relatively small 700B parameter count through improved post-training pipelines, and how this approach scales. Community discussion centered on the trade-offs between model size, efficiency, and practical deployability.

Interesting Points
  • Z.ai argues that parameter count is only meaningful alongside three other factors: data volume, compute allocation, and deployment conditions.
  • GLM 5.3 achieves frontier-level performance at a relatively small 700B parameter count through improved post-training pipelines.
  • The post suggests that Qwen 3.8 27B and DeepSeek v4 Flash demonstrate that improved post-training can significantly elevate model capabilities, especially on agentic and long-scale tasks.
  • Commenters discussed the trade-offs between extending training time, compression techniques, and MoE architectures for smaller models.
Top Comments

Interesting write up. So GLM 5.3 is an experiment of sorts. It makes sense though, we saw how Qwen 3.8 27B is an excellent model, and part of that comes from how much reasoning it uses. GLM 5.3 seems to just be an upsized example of that, which is promising since we know that this scales. Hopefully this puts GLM 5.5 in a good spot, apparently it's set to be Deepseek v4 pro sized. So comparatively small now compared to most models, which hopefully also means it's cost effective.

u/Few_Painter_5588 (83 points · permalink)

Where are all the clowns still thinking Chinese labs aren't capable of frontier artificial intelligence and that all they do is distill Claude/GPT models?

u/jonydevidson (47 points · permalink)

Which brings us to this release. Total parameters appear to matter up to a threshold — enough to hold the world — after which additional capability comes from scaling elsewhere

I've begun a project working on a refit of Llama 8b specifically because of this.

I suspected that 8b with better architecture could WAY out perform the expectation if I gave it Deepseek's Engram tech.

So as a side experiment I built that out. It's cool because it uses less compute and VRAM than one might think.

Engram trades RAM for VRAM. So an 8b model (which will end up ~9b) will store "world knowledge" aside from computational ability. There's no real reason to store knowledge within the computational graph. If you can effectively train the model with the ability to fetch that information, then you can leverage the 8b parameters harder against computation versus it needing to understand things that are unlikely to change. All while still capable of being to update those things changing during computation.

The downside is that right now it seems like you need ~32gb of available RAM to hold a full table in memory (The "world knowledge") while the VRAM only handles the 8b model.

Kind of interestingly from my research, you can keep the same 32gb of RAM storage while heavily quantizing the model.

World knowledge lives in a specific subsection of the weights where it's most destroyed during the quantization phase. This means pushing a model to Q4 or something has near zero impact because the FP16 or FP8 weight table still exists in RAM memory.

The fetch exercise isn't PCIe bound on DDR5 from what I can tell.

The reasoning that DS v4 probably didn't deploy the architecture is that serving it at scale with a massive model would be a nightmare. You're both balancing this hash table of knowledge against the VRAM constraints.

On smaller models it allows for much better effective GPU saturation without destroying VRAM bandwidth. So that's interesting I guess.

When finished? Who knows. This is love of the game kind of research.

u/NineThreeTilNow (21 points · permalink)


Stop Anthropomorphisizing Intermediate Tokens: Qwen3.8 doesn't 'overthink'

424 points · 224 comments · r/LocalLLaMA · by u/ThirdWaveCat

Screenshot of a research paper on anthropomorphizing intermediate tokens in LLMs

A discussion sparked by a paper arguing that anthropomorphizing LLM intermediate tokens — calling them 'reasoning' or 'thinking' — confuses how these models actually work and leads to questionable research. The post argues that terms like 'overthinking' in the Qwen 3.8 context are misleading metaphors that obscure the real issue: excessive test-time compute spent on derivational traces. The paper claims this anthropomorphization is not harmless and actively harms effective model usage.

Interesting Points
  • The linked paper argues that calling derivational traces 'reasoning' confuses the nature of autoregressive token prediction and leads to questionable research directions.
  • The discussion highlights that the real concern with Qwen 3.8 is not anthropomorphism but excessive test-time compute spent on reasoning traces that don't improve output quality.
  • Commenters compared the debate to the earlier 'hallucinations' terminology controversy — imperfect terms that help people conceptualize what's happening.
  • The paper's authors note that the terms used to describe LLM internals directly influence how researchers design experiments and how users configure their models.
Top Comments

Have you met a human?

u/tomvorlostriddle (201 points · permalink)

"Stop calling the deleted file collector in OSs the recycling bin. It misleads humans into thinking it is a literal bin with the capability of recycling files."

This constant policing of terms relating to LLMs is so frustrating, it seems to just ignore the fact that we've always used metaphors to explain concepts relating to computing.

No, of course LLM thinking and reasoning aren't the same as human thinking and reasoning, but it is roughly analogous and close enough for the terms to be apt.

u/FrostTactics (181 points · permalink)

i don't even disagree, i've stated here that traces aren't for the user, they're for the LLM to plumb the depths of their internal distribution more fully. however, any paper like this that is worded as a command will always land like a box of rocks, people don't like being ordered around.

u/llama-impersonator (119 points · permalink)

This was just like the whining over "hallucinations" as a term. It's an imperfect term, but helps people conceptualize what's going on with the LLM.

Qwen 3.8 doesn't genuinely overthink, but people do feel it spends too much on test-time compute.

u/adcimagery (72 points · permalink)

Note that the authors got called out for framing their findings broadly with experiments based on small models (smaller than 8b), a reviewer brought this up, so they ran the experiments on qwen 8b (lora) and tried to present the results as if it painted the same picture despite it actually underperforming compared to the small models. That's only up to 8b, and already different than what they claimed. Their only move toward a realistically pretrained LLM already changes the headline result, and they then stop scaling. They could've presented a much more neutral paper instead of trying to push some exceptionalism slop they had no proof to back up.

u/PunnyPandora (38 points · permalink)


and here we are

422 points · 167 comments · r/LocalLLaMA · by u/johnnyApplePRNG

and here we are

A post comparing the economics of local AI inference to cloud alternatives, noting that a $900 high-VRAM GPU setup can match or exceed cloud model capabilities over a 1.5-month period. The post sparked extensive debate about the cost-effectiveness of local inference versus cloud APIs, with commenters pointing out that local hardware can be competitive for heavy users but may not justify the upfront investment for casual users.

Interesting Points
  • A $900 GPU setup was compared against cloud inference costs over a 1.5-month period, suggesting local hardware can be cost-competitive for heavy users.
  • Commenters noted that the only real reasons to do local inference are learning as a hobby, privacy concerns, or enterprise-scale deployment.
  • Some users pointed out that cloud models like GPT-5.6 Sol have usage limits that can be hit even on the $200 plan, making local hardware attractive for large projects.
  • The post highlighted the ongoing tension between local AI enthusiasts and cloud API users regarding cost and capability trade-offs.
Top Comments

1.5 months? 900$ high VRAM GPU?

3090 + quantized Qwen 3.8 27B vs GPT-5.6 Sol with huge limits, I wonder what will be more cost effective...

u/Fedor_Doc (151 points · permalink)

With local you're never gonna match the quality and speed of cloud, but what you will do is find that you either don't mind the wait or that the weaker model is still plenty good enough for your use case.

u/Squidgical (69 points · permalink)

No been my experience at all. I could max the $20 plan, but I can't on the ChatGPT $200 that I'm doing for a larger project.

u/PermanentLiminality (42 points · permalink)


Anthropic working on Claude autonomously designing drugs.

414 points · 68 comments · r/singularity · by u/borowcy

Anthropic published research showing Claude can autonomously design protein binders from scratch, achieving a 22-35% success rate depending on the setup, compared to the typical 10-15% in the field. Claude designed binders against 14 out of 15 targets in controlled experiments, with some of its strongest designs binding several times more tightly than the best published de novo binders. The work was done in partnership with Adaptyv Bio and Twist Bioscience, who independently built and tested the proteins Claude designed.

Interesting Points
  • Claude achieved a 22-35% success rate in designing protein binders, compared to the typical 10-15% in the field today.
  • Claude designed binders against 14 out of 15 targets in controlled experiments using multiple 24-hour sessions.
  • Some of Claude's strongest designs bound several times more tightly than the best published de novo binder.
  • The work was independently validated by Adaptyv Bio and Twist Bioscience, who built and tested the proteins Claude designed.
  • The research raises dual-use concerns, as the same capabilities that can design beneficial drugs could also design bioweapons.
Top Comments

Ironically, I believe that science is one of the areas where hallucination doesn't actually matter too much. We're used to most of our experiments not working so we automatically control for everything anyway. 10% added failure rate is fine in discovery and proof of concept testing.

u/Lithgow_Panther (109 points · permalink)

we found that Mythos Preview achieves an overall hit rate of 35.1% when designing against each target separately using multiple 24-hour sessions.

That is a crazy statement when

10 to 15% is typical in protein design campaigns today.

u/MFpisces23 (31 points · permalink)

If a beneficial drug can be designed, then a bioweapon can also be designed. And that's scary. Alignment is a serious topic that we cannot put too much resources into.

u/Halpaviitta (12 points · permalink)


Codex Patched My Samsung Odyssey G9 Firmware to Add a New Gaming Crosshair

364 points · 63 comments · r/ChatGPT · by u/manikfox

Codex Patched My Samsung Odyssey G9 Firmware to Add a New Gaming Crosshair

A user successfully used ChatGPT's Codex to write a binary patch for their Samsung Odyssey G9 monitor's firmware, adding a custom gaming crosshair feature. The user described the process as risky, as the patch was applied without the ability to validate or test it beforehand. The post generated significant discussion about the bravery and risk involved in letting AI modify firmware without a rollback plan, though the patch ultimately succeeded.

Interesting Points
  • The user used Codex to write a binary patch for their Samsung Odyssey G9 monitor's firmware to add a custom crosshair feature.
  • The patch was applied without the ability to validate or test it beforehand, making it a significant risk to a $1,000 monitor.
  • Some commenters noted that the G9 already has a built-in crosshair mode, suggesting the user's motivation was aesthetic preference rather than functionality.
  • The post demonstrates the growing capability of AI coding agents to handle low-level firmware modification tasks.
Top Comments

That was BRAVE of you. Glad it worked out

u/desatur8 (314 points · permalink)

This is the kind of stuff that really interests me. I can only take so many one-shot Minecraft clones. Let's see some more of this!

Very cool.

u/Ctrl-Alt-Panic (42 points · permalink)

That's actually wild. Now let's give us back our brightness

u/NairbHna (23 points · permalink)


Teachers Warn That Students Are Losing the Ability to Think as They Lean on AI for Everything

360 points · 239 comments · r/ArtificialInteligence · by u/Actual__Wizard

Teachers are warning that students are losing their ability to think independently as they increasingly rely on AI for all tasks. A study of 26,811 Chinese students found that AI adoption raised homework scores by 18% and reduced completion time by 30%, but lowered monthly exam scores by 20% within six months. High-stakes entrance-exam scores fell by 18-24%, with the full penalty emerging only after about two years. The learning losses were concentrated among roughly 80% of AI users whose behavior was consistent with homework outsourcing.

Interesting Points
  • A 30-month panel study of 26,811 Chinese students in grades 7-12 found AI adoption raised homework scores by 18% but lowered monthly exam scores by 20% within six months.
  • High-stakes entrance-exam scores fell by 18 and 24%, with the full penalty emerging only after about two years of AI use.
  • The losses were largest in social science subjects, followed by STEM and languages, and were especially large for junior students, high-achieving students, and boys.
  • Learning losses were concentrated among roughly 80% of AI users whose behavior was consistent with homework outsourcing, indicated by exceptionally short homework completion time coupled with high homework scores.
Top Comments

Chatgpt, explain why this is happening, no mistakes.

u/whitehypeman (166 points · permalink)

That is because the education system views AI as a method to cheat rather than accepting that it exists and will be used whether they like it or not.

We need to re-think what and how we teach kids and emphasize and focus on being curious.

Currently, a terminally curious person with no qualifications will run laps around a credentialed individual that is set in their ways and beliefs.

Burying our heads in the sand and blaming AI is just enabling the outcome we all fear.

u/WhaleFactory (126 points · permalink)

we're in the end game now. it'll all be over soon.

u/zero989 (13 points · permalink)

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6868618

Abstract

Using 30 months of panel data on 26,811 Chinese students in grades 7-12, we study how generative AI affects homework productivity and learning. The data combine monthly closed-book exams, high-school and college entrance exams, and homework scores and completion time across nine subjects. We exploit staggered AI adoption in a difference-in-differences design. AI adoption raises homework scores by 18% and reduces completion time by 30%, but lowers monthly exam scores by 20% within six months. High-stakes entrance-exam scores fall by 18 and 24%, with the full penalty emerging only after about two years. The losses are largest in social science subjects, followed by STEM and languages, and are especially large for junior students, high-achieving students, and boys. The learning losses are concentrated among roughly 80% of AI users whose behavior is consistent with homework outsourcing, as indicated by exceptionally short homework completion time coupled with high homework scores. AI users who maintain similar homework completion time as non-AI users experience small learning losses.

u/NoRegreds (9 points · permalink)

Go back to oral exams.

u/TheMrCurious (8 points · permalink)


We have Q3.8 35B at home: 3x new Ornith 1.5 released

357 points · 167 comments · r/LocalLLaMA · by u/AppealSame4367

Ornith 1.5 model family on Hugging Face

A community member shared three new Ornith 1.5 models — a 9B, a 35B-A3B MoE, and a 397B MoE — claiming they surpass Qwen 3.8 27B on several benchmarks including Terminal Bench 2.1, SWE Bench Pro, and DeepSWE. The 397B model claims to beat DeepSeek V4 Flash 0731 and Opus 4.8. The post was framed as a joke about Qwen 3.8 35B, with the poster noting the models have the benchmark values they would expect from a hypothetical Qwen 3.8 35B release. Community response was skeptical, with many noting that self-reported benchmarks from fine-tune authors are often unreliable.

Interesting Points
  • Ornith 1.5 claims their 35B-A3B model surpasses Qwen 3.6 27B and even Qwen 3.8 27B on the NL2Repo benchmark.
  • The 397B model claims to beat DeepSeek V4 Flash 0731 and Opus 4.8 on unspecified benchmarks.
  • The 35B-A3B model includes MTP (Multi-Token Prediction) heads, with blk.40 dedicated to next-token prediction.
  • Community members noted that Ornith 1.0 was worse than the base model for many users, with reports of 'doom reasoning loops.'
  • The 9B model was highlighted as particularly interesting by some commenters for its performance on 8GB VRAM setups.
Top Comments

I compared the values with Q3.8 27B: What they claim is that their 35B surpasses Q3.6 27B (Terminal Bench 2.1, SWE Bench Pro, DeepSWE) and even overtake Q3.8 27B in NL2Repo benchmark.

They claim that their 397B surpasses DeepSeek V4 Flash 0731 and Opus 4.8.

https://huggingface.co/Qwen/Qwen3.8-27B

True if big.

u/AppealSame4367 (110 points · permalink)

It's mainly a fine-tune of Qwen 3.6, not 3.8.

u/Ok-District-1756 (37 points · permalink)

I had been using ornith 35b v1 for a while. Qwen 3.8 is a huge step up from my experience. I doubt v1.5 will catch 3.8 if Qwen doesn't do a 35b, but would be a pretty good option if you're gpu limited.

u/iplaythisgame2 (30 points · permalink)

The benchmarks they show have the 397B model beating GLM 5.2? That's pretty impressive.

u/hainesk (29 points · permalink)

Benchmarks are meaningless. DeepSWE went from 0 to 21. You know why? Not because the LLM suddenly realized how to debug multi file repos, but because they consciously trained the model on deepswe's public dataset which was released after qwen3.6

u/Gohab2001 (24 points · permalink)

Same story in 2 more subreddits: r/LocalLLaMA

Ornith-1.5 (397B [DeepSWE 56], 35B-A3B, 9B)

183 points · 68 comments · r/LocalLLaMA · by u/KokaOP

Ornith 1.5: 9B dense and 35B/397B MoEs

56 points · 10 comments · r/LocalLLaMA · by u/tarruda


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